Designing a Multi-Epitope Subunit Vaccine against VP1 Major Coat Protein of JC Polyomavirus

The JC polyomavirus virus (JCPyV) affects more than 80% of the human population in their early life stage. It mainly immunocompromised individuals where replication oligodendrocytes and astrocytes may lead to fatal progressive multifocal encephalopathy (PML). Virus protein 1 (VP1) is one major structural proteins viral capsid, responsible for keeping alive gastrointestinal urinary tracts. VP1 often targeted antiviral drug vaccine development. Similarly, this study implied immune-informatics molecular modeling methods design a multi-epitope subunit targeting JCPyV. epitopic sequences, which are highly conserved, were used build vaccine. This designed includes two adjuvants, five HTL epitopes, CTL BCL epitopes stimulate cellular, humoral, innate immune responses against Furthermore, dynamics simulation (100 ns) studies examine interaction stability with TLR4. Trajectory analysis showed that TLR4 receptor form stable complex. Overall, contribute path development